Curcumin Increase the Expression of Neural Stem/Progenitor Cells and Improves Functional Recovery after Spinal Cord Injury
10.3340/jkns.2017.0203.003
- Author:
Woo Seok BANG
1
;
Kyoung Tae KIM
;
Ye Jin SEO
;
Dae Chul CHO
;
Joo Kyung SUNG
;
Chi Heon KIM
Author Information
1. Department of Neurosurgery, Kyungpook National University Hospital, Daegu, Korea. nskimkt7@gmail.com
- Publication Type:Original Article
- Keywords:
Curcumin;
Spinal cord injuries;
Neural stem progenitor cells;
Lesion cavity;
Astrogliosis;
Functional recovery
- MeSH:
Adult;
Animals;
Curcumin;
Glial Fibrillary Acidic Protein;
Humans;
Male;
Rats;
Rats, Sprague-Dawley;
Spinal Cord Injuries;
Spinal Cord
- From:Journal of Korean Neurosurgical Society
2018;61(1):10-18
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To investigates the effect of curcumin on proliferation of spinal cord neural stem/progenitor cells (SC-NSPCs) and functional outcome in a rat spinal cord injury (SCI) model.METHODS: Sixty adult male Sprague-Dawley rats were randomly and blindly allocated into three groups (sham control group; curcumin treated group after SCI; vehicle treated group after SCI). Functional recovery was evaluated by the Basso, Beattie, and Bresnahan (BBB) scale during 6 weeks after SCI. The expression of SC-NSPC proliferation and astrogliosis were analyzed by nestin/Bromodeoxyuridine (BrdU) and Glial fibrillary acidic protein (GFAP) staining. The injured spinal cord was then examined histologically, including quantification of cavitation.RESULTS: The BBB score of the SCI-curcumin group was better than that of SCI-vehicle group up to 14 days (p < 0.05). The co-immunoreactivity of nestin/BrdU in the SCI-curcumin group was much higher than that of the SCI-vehicle group 1 week after surgery (p < 0.05). The GFAP immunoreactivity of the SCI-curcumin group was remarkably lower than that of the SCI-vehicle group 4 weeks after surgery (p < 0.05). The lesion cavity was significantly reduced in the curcumin group as compared to the control group (p < 0.05).CONCLUSION: These results indicate that curcumin could increase the expression of SC-NSPCs, and reduce the activity of reactive astrogliosis and lesion cavity. Consequently curcumin could improve the functional recovery after SCI via SC-NSPC properties.
