Deep Brain Stimulation for the Treatment of Medically Intractable Epilepsy: a Review on Clinical Application
- Author:
Young Min SHON
1
Author Information
1. Department of Neurology, The Catholic University of Korea, College of Medicine, Seoul, Korea. sonogung@catholic.ac.kr
- Publication Type:Review
- Keywords:
Deep brain stimulation;
Intractable epilepsy;
Anterior thalamic nucleus;
SANTE;
Responsive neurostimulation
- MeSH:
Anterior Thalamic Nuclei;
Brain;
Deep Brain Stimulation;
Electrodes;
Epilepsy;
Intralaminar Thalamic Nuclei;
Light;
Patient Selection;
Seizures;
Subthalamic Nucleus;
Thalamus
- From:Journal of Korean Epilepsy Society
2012;16(1):9-13
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
It has been suggested that epileptic seizures can be interrupted by deep brain stimulation (DBS) of various deep brain structures which may exert a therapeutic control on seizure generators or correspond to ictal onset zone themselves. Several groups have used DBS in drug-resistant epilepsy cases for which resective surgery cannot be applied. The promising subcortical brain structures are anterior and centromedian nucleus of the thalamus, subthalamic nucleus, and other nuclei to treat epilepsy in light of previous clinical and experimental data. Recently two randomized trials of neurostimulation for controlling refractory epilepsy employed the strategies to stimulate electrodes placed on both anterior thalamic nuclei or near seizure foci in response to electroencephalographically detected epileptiform activity. However, the more large-scale, long-term clinical trials which elucidates optimal stimulation parameters, ideal selection criteria for epilepsy DBS should be performed before long.
