Clinical Manifestations of Subependymal Giant Cell Astrocytoma in Tuberous Sclerosis Patients
- Author:
Hee Joon YU
1
;
Cha Gon LEE
;
Jeehun LEE
;
Hyung Jin SHIN
;
Munhyang LEE
Author Information
1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. mhlee091@skku.edu
- Publication Type:Original Article
- Keywords:
Subependymal giant cell astrocytoma;
Tuberous sclerosis complex;
Tumor
- MeSH:
Astrocytoma;
Follow-Up Studies;
Headache;
Humans;
Neoplasm, Residual;
Recurrence;
Retrospective Studies;
Seizures;
Tuberous Sclerosis;
Vision, Ocular;
Vomiting
- From:Journal of Korean Epilepsy Society
2011;15(1):24-30
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We described the presenting symptoms, radiologic features and postoperative course of subependymal giant cell astrocytoma (SEGA) in tuberous sclerosis complex (TSC) patients.METHODS: This is a retrospective study including 12 patients (M:F=9:3) who were pathologically confirmed as SEGA between March 1998 and May 2011.RESULTS: Five teenage patients consisted of four who presented with recently appeared headache, vomiting and visual symptoms and one with seizure were never diagnosed as TSC before this presentation. The others (n=7) presented with seizure and diagnosed with TSC before three years of age, and they were diagnosed as SEGA after median 6.5 (2-14) years. The presenting symptoms were headache or vomiting (n=7), blurred vision (n=3), weakness (n=2) and increased seizure frequency (n=1). Four patients experienced tumor recurrence between five months and three years of follow-up; surgical tumor removal (n=1) and gamma knife surgery (n=3) were done for the recurred tumor. The size of residual tumor increased in two patients and repeated tumor removal was done.CONCLUSIONS: Most of SEGA presented with new onset headache, vomiting and visual symptoms. After surgery, the tumor recurred in 25% of patients. Serial follow-up is essential to detect new lesion and find tumor recurrence in patients with SEGA.
