A Case of Pediatric Precursor B-cell Acute Lymphoblastic Leukemia Associated with Translocations (14;18)(q32;q21) and (8;9)(q24;p13)
10.15264/cpho.2017.24.2.148
- Author:
Hye Ji KIM
1
;
Hyery KIM
;
Kyung Nam KOH
;
Ho Joon IM
;
Jong Jin SEO
;
Eul Ju SEO
;
Chan Jeoung PARK
Author Information
1. Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. jjseo@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Pediatric;
Precursor B-cell lymphoblastic leukemia;
Translocations;
MYC;
BCL2
- MeSH:
Adolescent;
Adult;
Cytarabine;
Humans;
Induction Chemotherapy;
Leukemia;
Male;
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Precursor Cells, B-Lymphoid;
Prognosis
- From:Clinical Pediatric Hematology-Oncology
2017;24(2):148-152
- CountryRepublic of Korea
- Language:English
-
Abstract:
Precursor B-cell acute lymphoblastic leukemia (ALL), which is the most common subtype of pediatric acute leukemia, generally has a good prognosis. However, the prognosis also depends on the genetic abnormalities of the leukemic blast. Concurrent MYC and IGH/BCL2 translocations have recently been reported as a “double hit” in adult patients, but non-immunoglobulin (non-IG)/MYC translocation has rarely been reported. In this paper, we report a case of pediatric precursor B-cell ALL associated with translocations (14;18)(q32;q21) and (8;9)(q24;p13). The patient was a previously healthy 13-year-old boy. Complete remission was not achieved after first-line four-drug induction chemotherapy; thus, intensive salvage regimen, including high-dose cytarabine and L-asparaginase, were administered, which resulted in morphologic remission. However, his disease relapsed during the second cycle of salvage regimen, and he died of sepsis-induced multiorgan failure.
