Neonatal Hepatic Hemangioendothelioma: A Single Institute Experience
10.15264/cpho.2016.23.1.46
- Author:
Leehuck GIL
1
;
Ki Young YOO
;
Hyun Joo JUNG
;
Jun Eun PARK
Author Information
1. Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea. pedpje@ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Hemangioendothelioma;
Neonatal;
Hepatic;
Tumor
- MeSH:
Diagnosis;
Heart Failure;
Hemangioendothelioma;
Hepatic Artery;
Hepatomegaly;
Humans;
Interferon-alpha;
Liver;
Remission, Spontaneous;
Retrospective Studies;
Thrombocytopenia;
Ultrasonography, Prenatal
- From:Clinical Pediatric Hematology-Oncology
2016;23(1):46-52
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Hepatic hemagioendothelioma in neonatal period was rarely seen, so standard treatment does not established yet.METHODS: A retrospective analysis of patients with neonatal hepatic hemangioendothelioma at Ajou University Hospital between 2001 and 2016 was performed.RESULTS: Six patients with hepatic hemangioendothelioma in neonatal period were founded. Mean age at diagnosis was 6.1 days (range, 1-26 days). Three patients have no symptoms; diagnostic approach was prenatal ultrasonography in 2 patients, and incidental abnormal ultrasonographic findings in 1 patient, but the other 3 patients have hepatomegaly and/or congestive heart failure. Three patients were observed without treatment and the other 3 patients received medical and/or surgical treatment. Three patients of those who did not receive treatment became spontaneous regression. Of the other 3 patients, 1 patient achieved complete tumor disappearance after surgical resection, another 1 patient achieved to decrease tumor size with interferon-alpha treatment for 6 months and then had complete resolution of tumor after partial liver lobectomy, and other 1 patient who received hepatic artery embolization decreased in the size and number of lesions and then regressed gradually.CONCLUSION: Asymptomatic patients with neonatal hepatic hemangioendothelioma could have spontaneous remission, but patients with symptoms such as hepatomegaly with congestive heart failure or thrombocytopenia needed to be applied with medical and/or surgical treatment.
