A Case of Diffuse Neonatal Hemangiomatosis Successfully Treated with Propranolol
10.15264/cpho.2016.23.1.61
- Author:
Seung Yeon JEONG
1
;
Mee Jeong LEE
;
Jeesuk YU
Author Information
1. Department of Pediatrics, Dankook University College of Medicine, Cheonan, Korea. LMJPED@hanmail.net
- Publication Type:Case Report
- Keywords:
Diffuse neonatal hemangiomatosis;
Propranolol;
Liver hemangioma
- MeSH:
Administration, Oral;
Bronchoconstriction;
Chin;
Female;
Heart Failure;
Hepatomegaly;
Humans;
Hypoglycemia;
Hypotension;
Hypothyroidism;
Liver;
Prednisolone;
Propranolol;
Psychomotor Agitation;
Thigh;
Thyroid Function Tests;
Thyroid Gland;
Thyroxine
- From:Clinical Pediatric Hematology-Oncology
2016;23(1):61-64
- CountryRepublic of Korea
- Language:English
-
Abstract:
We present a case of a 41-day-old girl with diffuse hemangiomatosis on her chin, right thigh, occipital area, and liver. She also had hepatomegaly, heart failure, and hypothyroidism. Hemangiomatosis did not respond to 2 weeks of oral administration of prednisolone, but was successfully treated with propranolol. After 2 years of propranolol treatment, the lesions of hemangiomatosis nearly disappeared. Hypothyroidism was controlled by levothyroxine replacement. As hemangiomatosis regressed, thyroid function was normalized. Propranolol may have adverse effects including hypotension, hypoglycemia, bronchoconstriction, and restlessness, but she did not experience such adverse effects. Propranolol could be the first choice for diffuse neonatal hemangiomatosis (DNH). Our case also suggests that thyroid function test is needed in patient with DNH.
