Invasive Pulmonary Aspergillosis after Recent Influenza in a Child with Acute Myeloid Leukemia
10.15264/cpho.2015.22.2.190
- Author:
Beom Joon KIM
1
;
Seong koo KIM
;
Seung Beom HAN
;
Jae Wook LEE
;
Jong Seo YOON
;
Nack Gyun CHUNG
;
Bin CHO
;
Jin Han KANG
;
Hack Ki KIM
Author Information
1. Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. beomsid@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Influenza;
Invasive pulmonary aspergillosis;
Hematopoietic stem cell transplantation;
Acute myeloid leukemia;
Child
- MeSH:
Adolescent;
Bronchiolitis Obliterans;
Cell Transplantation;
Child;
Dyspnea;
Fever;
Glucocorticoids;
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation;
Humans;
Influenza, Human;
Invasive Pulmonary Aspergillosis;
Leukemia, Myeloid, Acute;
Male;
Oseltamivir;
Polymerase Chain Reaction;
Risk Factors;
Thorax;
Transplants
- From:Clinical Pediatric Hematology-Oncology
2015;22(2):190-194
- CountryRepublic of Korea
- Language:English
-
Abstract:
Respiratory viral infection has been reported as a risk factor for invasive pulmonary aspergillosis (IPA) in hematopoietic cell transplantation (HCT) recipients, and IPA following influenza has been reported. We report a 13-year-old boy diagnosed with IPA following influenza. He received allogeneic HCT and then received glucocorticoids for chronic graft-versus-host disease. On admission, he complained of non-neutropenic fever and dyspnea. He was diagnosed with influenza A via a polymerase chain reaction (PCR) test from nasopharyngeal swab, and oseltamivir was administered. Fever re-emerged nine days later and repeat PCR was positive for influenza A. His fever did not resolve despite triple antiviral and empirical antibiotic therapy. On hospital day 22, IPA was diagnosed based on chest computed tomography and positive serum galactomannan results, and his symptoms improved with voriconazole therapy. However, he died of uncontrolled bronchiolitis obliterans on hospital day 128. IPA should be considered a complication of influenza in immunocompromised children.
