Evaluation of Cardiac Function in Children with Solid Tumors, who Underwent Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation
10.15264/cpho.2014.21.2.121
- Author:
Yoo Seon KIM
1
;
Jinyoung SONG
;
Ki Woong SUNG
;
Soo Hyun LEE
;
Keon Hee YOO
;
June HUH
;
I Seok KANG
;
Hong Hoe KOO
Author Information
1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. amyjys@naver.com
- Publication Type:Original Article
- Keywords:
High-dose chemotherapy;
Autologous;
Stem cell transplantation;
Cardiac function;
Echocardiography
- MeSH:
Child;
Diagnosis;
Doxorubicin;
Drug Therapy;
Echocardiography;
Follow-Up Studies;
Heart;
Heart Failure;
Humans;
Prognosis;
Radiotherapy;
Retrospective Studies;
Stem Cell Transplantation;
Stroke Volume;
Survival Rate;
Survivors
- From:Clinical Pediatric Hematology-Oncology
2014;21(2):121-127
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Even though the five year survival rate and prognosis of childhood solid tumors have been improved through the introduction of dose-escalation using tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT), changes in cardiac function have not yet been studied. We therefore evaluated cardiac function after tandem HDCT/auto-SCT.METHODS: This study retrospectively analyzed 56 pediatric patients who were diagnosed with solid tumors and who underwent tandem HDCT/auto-SCT at Samsung Medical Center. We investigated the cardiac function of these patients using echocardiography to evaluate the parameters of the left ventricular ejection fraction, e/e', and left ventricular Tei index.RESULTS: The mean left ventricular ejection fraction, e/e', and left ventricular Tei index at one year after the second HDCT/auto-SCT were 65.7%, 0.32, and 8.6, respectively. When compared those with before the first tandem HDCT/auto-SCT, there were no significant negative changes. We evaluated the changes in cardiac function in different subgroups, based on doxorubicin, radiotherapy involving heart, and the age of the patient at diagnosis. There were no significant changes of cardiac function after the treatment in any of the subgroups. Clinical heart failure did not develop in any of the patients.CONCLUSION: This study showed no significant negative changes in cardiac function at one year after tandem HDCT/auto-SCT. However, long-term follow-up studies of cardiac function in survivors and further studies of cardiac function are needed.
