Low Dose Methotrexate induced Bullous Acral Erythema in a Child with Acute Lymphoblastic Leukemia
- Author:
So Yeo CHO
1
;
Jae Hee LEE
Author Information
1. Department of Pediatrics, Chosun University School of Medicine, Gwangju, Korea. pedjhl@gmail.com
- Publication Type:Case Report
- Keywords:
Acral erythema;
Chemotherapy side effect;
Methotrexate
- MeSH:
Adolescent;
Child;
Diagnosis, Differential;
Drug Therapy;
Erythema;
Female;
Foot;
Hand;
Hand-Foot Syndrome;
Humans;
Methotrexate;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Skin
- From:Clinical Pediatric Hematology-Oncology
2014;21(2):168-171
- CountryRepublic of Korea
- Language:English
-
Abstract:
Chemotherapy-induced acral erythema (CIAE) is an uncommon, self-limited local skin reaction that usually occurs after high-dose chemotherapy. There is no specific treatment for this disease and it disappears within three to five weeks. In this case report, we present a 16-year-old female with acute lymphoblastic leukemia who developed severe CIAE. The lesions appeared as a well-defined erythema of the hands, feet, and back with symmetrically well-defined borders 5 days after low-dose MTX treatment. The erythema progressed to bullae formation and desquamation. It resolved spontaneously within 2 weeks. CIAE is very uncommon in children; however we should consider acral erythema as a differential diagnosis when bullous skin reaction occurs in a patient who receives chemotherapy.
