A Case of Osteosarcoma after Treatment of Endodermal Sinus Tumor
- Author:
Dahee JIN
1
;
Yoon LEE
;
Jung Hwa LEE
;
Kwang Chul LEE
;
Chul Hwan KIM
Author Information
1. Department of Pediatrics, Korea University College of Medicine, Seoul, Korea. kwcl5609@korea.ac.kr
- Publication Type:Case Report
- Keywords:
Endodermal sinus tumor;
Osteosarcoma;
Second primary neoplasm
- MeSH:
Biopsy;
Bleomycin;
Child;
Cisplatin;
Drug Therapy;
Endodermal Sinus Tumor;
Etoposide;
Female;
Femur;
Follow-Up Studies;
Humans;
Knee Joint;
Methotrexate;
Neoplasms, Germ Cell and Embryonal;
Neoplasms, Second Primary;
Osteoblasts;
Osteosarcoma;
Radiotherapy;
Recurrence;
Thigh
- From:Clinical Pediatric Hematology-Oncology
2014;21(1):41-45
- CountryRepublic of Korea
- Language:English
-
Abstract:
Endodermal sinus tumor is a type of germ cell tumor that is relatively common in children. An important problem concerns secondary neoplasms after treatment. We report a case of osteosarcoma that developed five years after treatment of intrapelvic endodermal sinus tumor. The patient was a seven-year-old girl who presented with right thigh and knee joint pain. The patient had been diagnosed with endodermal sinus tumor five years previously and treated with a regimen consisting of high dose cisplatin, etoposide, bleomycin and surgery but without radiotherapy. We detected a mass shadow on the right distal femur that proved to be osteoblastic osteosarcoma by incisional biopsy. The patient received surgical treatment after chemotherapy that included high dose methotrexate. The follow-up bone scan revealed no abnormal uptakes. There has been no evidence of recurrence eighteen months of follow-up after chemotherapy.
