Pneumatosis Intestinalis Developed due to CMV Infection in a Pediatric Severe Aplastic Anemia Patient after Hematopoietic Stem Cell Transplantation
- Author:
Min Gyu SEON
1
;
Hyun Joo JUNG
;
Oh Kyu NOH
;
Jun Eun PARK
Author Information
1. Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea. pedpje@ajou.ac.kr
- Publication Type:Case Report
- Keywords:
Pneumatosis intestinalis;
CMV infection;
Graft-versus-host disease;
Hematopoietic stem cell transplantation
- MeSH:
Abdominal Pain;
Anemia, Aplastic;
Antilymphocyte Serum;
Busulfan;
Diarrhea;
Female;
Fever;
Ganciclovir;
Gastrointestinal Hemorrhage;
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation;
Hematopoietic Stem Cells;
Humans;
Stem Cell Transplantation;
Stem Cells;
Unrelated Donors;
Vidarabine
- From:Clinical Pediatric Hematology-Oncology
2013;20(2):112-115
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 10-year old girl diagnosed as severe aplastic anemia was transplanted with peripheral stem cells from a CMV seropositive full matched unrelated donor. The conditioning regimen consisted of busulfan, fludarabine, and anti-thymocyte globulin (ATG). At D+114, abdominal pain, fever, and blood-tinged watery diarrhea developed. At D+116, pneumatosis intestinalis (PI) was detected on simple abdominal X-ray and computed tomography (CT). Ganciclovir was started intravenously because CMV antigenemia was detected at D+117. Two days later, PI sign disappeared on simple abdominal X-ray, and hematochezia began to decrease. CMV antigenemia disappeared 10 days after starting ganciclovir. We describe a 10-year old girl with severe aplastic anemia who developed PI in the presence of CMV infection and gastro-intestinal graft-versus-host-disease (GVHD) after allogeneic stem cell transplantation and was treated successfully with ganciclovir.
