Early-onset Pericardial Effusion after Autologous Hematopoietic Stem Cell Transplantation in a Child with Neuroblastoma
- Author:
Jong Hyung YOON
1
;
Hak Jin KIM
;
Su Jin KIM
;
Yong Soo YUN
;
Jong In CHUN
;
Hyeon Jin PARK
;
Byung Kiu PARK
Author Information
1. Center for Pediatric Oncology, National Cancer Center, Goyang, Korea. bkpark@ncc.re.kr
- Publication Type:Case Report
- Keywords:
Pericardial effusion;
Autologous hematopoietic stem cell transplantation;
Transplantation-associated thrombotic microangiopathy
- MeSH:
Child;
Drug Therapy;
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation;
Hematopoietic Stem Cells;
Humans;
Neuroblastoma;
Pericardial Effusion;
Preschool Child;
Purpura, Thrombotic Thrombocytopenic;
Thrombotic Microangiopathies;
Transplantation, Homologous
- From:Clinical Pediatric Hematology-Oncology
2013;20(2):121-125
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Pericardial effusion (PcE) is one of the uncommon complications after hematopoietic stem cell transplantation (HSCT). Although many causes are related with PcE after HSCT, PcE after HSCT is usually late-onset and can be presented as a sign of acute or chronic graft-versus-host disease in allogeneic transplantation. Previous reports of PcE after autologous HSCT are very uncommon. Transplantation-associated thrombotic microangiopathy (TA-TMA) is a kind of renal microvascular complications after HSCT, which is similar to thrombotic thrombocytopenic purpura. The authors report a case of early-onset PcE, which maybe resulted from TA-TMA, after high-dose chemotherapy and autologous peripheral blood HSCT in a 4-year-old child with neuroblastoma.
