Two Cases of Infant-onset Cutaneous Mastocytosis
- Author:
Min Jung CHO
1
;
Sung Soo JUNG
;
Min Kyung LEE
;
Jin PARK
;
Pyoung Han HWANG
Author Information
1. Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea.
- Publication Type:Case Report
- Keywords:
Mastocytosis;
Infant;
Urticaria pigmentosa;
Mastocytoma
- MeSH:
Abdominal Pain;
Biopsy;
Blister;
Child;
Diarrhea;
Extremities;
Flushing;
Forearm;
Humans;
Infant;
Mast Cells;
Mastocytoma;
Mastocytosis;
Mastocytosis, Cutaneous;
Pruritus;
Rare Diseases;
Skin;
Urticaria Pigmentosa
- From:Clinical Pediatric Hematology-Oncology
2012;19(2):105-108
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Mastocytosis is a rare disease in infants and children that characterized by a pathologic increase and accumulation of mast cells in one or more organs. Cutaneous mastocytosis is a typical presentation of pediatric-onset mastocytosis and often presents classical symptoms and signs related with mast cell mediator including pruritus, flushing, abdominal pain and Darier's sign. We present our experience with two rare cases of cutaneous mastocytosis, a 3-month-old boy and a 4-month-old boy. The former had a recurrent single brownish plaque with yellowish bullae in right forearm without any other symptom or sign. The latter had multiple brownish plaques in his trunk and extremities with intermittent diarrhea and Darier's sign. In each, a punch biopsy confirmed the diagnosis of solitary mastocytoma and urticaria pigmentosa. After 2weeks of anti-histamine and leukotriene antagonist therapy for symptom relief, both infants had no remnant skin lesion or symptoms.
