A Case of Oligodendroglioma after Treatment of Acute Lymphoblastic Leukemia in Childhood
- Author:
Sang Hoon SHIN
1
;
Bo Hyun CHUNG
;
Siegfried BAUER
;
Jung Hwa LEE
;
Kwang Chul LEE
Author Information
1. Department of Pediatrics, Korea University College of Medicine, Seoul, Korea. kwcl5609@korea.ac.kr
- Publication Type:Case Report
- Keywords:
Oligodendroglioma;
Childhood;
Acute lymphoblastic leukemia;
Cranial irradiation
- MeSH:
6-Mercaptopurine;
Asparaginase;
Biopsy;
Brain;
Brain Neoplasms;
Cranial Irradiation;
Cytarabine;
Doxorubicin;
Headache;
Humans;
Magnetic Resonance Imaging;
Male;
Methotrexate;
Oligodendroglioma;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Prednisone;
Recurrence;
Seizures;
Survivors;
Valproic Acid;
Vincristine;
Visual Acuity;
Young Adult
- From:Clinical Pediatric Hematology-Oncology
2012;19(2):118-122
- CountryRepublic of Korea
- Language:English
-
Abstract:
Secondary brain tumors after cranial irradiation have been reported in survivors of childhood acute lymphoblastic leukemia (ALL). We report a case of secondary oligodendroglioma, occurring in a 19-year-old male, 12 years after the diagnosis of ALL. He was treated with vincristine, asparaginase, doxorubicin, methotrexate, prednisone, 6-mercaptopurine and cytarabine followed by prophylactic cranial irradiation at the age of 7 years. After treatment of ALL was completed at the age of 10 years, he showed symptoms of seizure, headache and decreased visual acuity at the age of 19 years. Magnetic resonance imaging (MRI) of the brain showed a mass lesion which was revealed as low-grade oligodendroglioma by stereotactic biopsy. He was treated with cranial radiotherapy, followed by 4 cycles of chemotherapy composed of PCV (procarbazine, methyl-1-(2-chloroethyl)-1-nitrosourea (CCNU), and vincristine) for oligodendroglioma, and sodium valproate for seizure control. The patient showed stable disease and no recurrence of seizure 8 months after treatment.
