A Case of Secondary Precursor B-cell Acute Lymphoblastic Leukemia Occurring after Treatment of Hemophagocytic Lymphohistiocytosis
- Author:
Song I YANG
1
;
In sang JEON
Author Information
1. Department of Pediatrics, Graduate School of Medicine, Gachon University of Medicine and Science, Incheon, Korea. isjeon@gilhospital.com
- Publication Type:Case Report
- Keywords:
Acute lymphoblastic leukemia;
Hemophagocytic lymphohistiocytosis
- MeSH:
Etoposide;
Inflammation;
Killer Cells, Natural;
Leukemia;
Lymphohistiocytosis, Hemophagocytic;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Precursor Cells, B-Lymphoid;
T-Lymphocytes
- From:Clinical Pediatric Hematology-Oncology
2011;18(2):140-143
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hemophagocytic lymphohistiocytosis (HLH), although uncommon, is illustrated as a dramatic clinical presentation of multi-systemic inflammation due to the impaired activity of cytotoxic T-cell and NK cell. Etoposide, an important component of the HLH treatment, is thought to have a leukemogenic potential. Furthermore, it has been suggested that the underlying immunologic dysfunction in HLH might be involved in the occurrence of secondary leukemia. Only a few cases of secondary ALLs after HLH have been reported. We report herein a case of secondary precursor B-cell ALL which occurred after the treatment of HLH.
