Role of Recepteur D'origine Nantais on Gastric Cancer Development and Progression
10.4068/cmj.2017.53.3.178
- Author:
Sung Yeul YANG
1
;
Thi Thinh NGUYEN
;
Trong Thuan UNG
;
Young Do JUNG
Author Information
1. Department of Biochemistry, Chonnam National University Medical School, Gwangju, Korea. ydjung@chonnam.ac.kr
- Publication Type:Review
- Keywords:
Humans;
Stomach Neoplasms;
MET protein, human;
Proto-Oncogene Proteins c-met;
Phenotype
- MeSH:
Epidemiologic Studies;
Humans;
Neoplasm Metastasis;
Phenotype;
Protein-Tyrosine Kinases;
Proto-Oncogene Proteins c-met;
Stomach Neoplasms;
Survival Rate
- From:Chonnam Medical Journal
2017;53(3):178-186
- CountryRepublic of Korea
- Language:English
-
Abstract:
Recepteur d'origine nantais (RON) is a receptor tyrosine kinase belonging to the subfamily of which c-MET is the prototype. Large epidemiologic studies have confirmed the strong association between RON and gastric cancer development. Constitutive activation of RON signaling directly correlates with tumorigenic phenotypes of gastric cancer and a poor survival rate in advanced gastric cancer patients. In this review, we focus on recent evidence of the aberrant expression and activation of RON in gastric cancer tumors and provide insights into the mechanism of RON signaling associated with gastric cancer progression and metastasis. Current therapeutics against RON in gastric cancer are summarized.
