Anticoagulation Therapy during Extracorporeal Membrane Oxygenator Support in Pediatric Patients
10.4068/cmj.2017.53.2.110
- Author:
Hwa Jin CHO
1
;
Do Wan KIM
;
Gwan Sic KIM
;
In Seok JEONG
Author Information
1. Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
- Publication Type:Review
- Keywords:
Extracorporeal Membrane Oxygenation;
Extracorporeal Life Support;
Anticoagulation;
Pediatrics
- MeSH:
Adult;
Anticoagulants;
Cause of Death;
Critical Illness;
Extracorporeal Membrane Oxygenation;
Humans;
Membranes;
Oxygen;
Oxygenators;
Oxygenators, Membrane;
Pediatrics;
Salvage Therapy
- From:Chonnam Medical Journal
2017;53(2):110-117
- CountryRepublic of Korea
- Language:English
-
Abstract:
Extracorporeal membrane oxygenation (ECMO) is a salvage therapy for critically ill patients. Although ECMO is becoming more common, hemorrhagic and thromboembolic complications remain the major causes of death in patients undergoing ECMO treatments. These complications commence upon blood contact with artificial surfaces of the circuit, blood pump, and oxygenator system. Therefore, anticoagulation therapy is required in most cases to prevent these problems. Anticoagulation is more complicated in pediatric patients than in adults, and the foreign surface of ECMO only increases the complexity of systemic anticoagulation. In this review, we discuss the pathophysiology of coagulation, anticoagulants, and monitoring tools in pediatric patients receiving ECMO.
