Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea

Author: Sungsu LEE ¹ ; Han Seong JEONG ; Hyong Ho CHO
Author Information

1. Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea. victocho@hanmail.net
Publication Type:Original Article
Keywords: Hair Cells, Auditory; Regeneration; Transcription Factors; Hearing Loss
MeSH: Cochlea; Fibroblast Growth Factors; Hair Cells, Auditory; Hair; Hearing; Hearing Loss; Mechanoreceptors; Regeneration; Transcription Factors
From:Chonnam Medical Journal 2017;53(1):37-46
CountryRepublic of Korea
Language:English
Abstract: Cochlear sensory hair cells (HCs) are crucial for hearing as mechanoreceptors of the auditory systems. Clarification of transcriptional regulation for the cochlear sensory HC development is crucial for the improvement of cell replacement therapies for hearing loss. Transcription factor Atoh1 is the key player during HC development and regeneration. In this review, we will focus on Atoh1 and its related signaling pathways (Notch, fibroblast growth factor, and Wnt/β-catenin signaling) involved in the development of cochlear sensory HCs. We will also discuss the potential applicability of these signals for the induction of HC regeneration.