Circulating Tumor Cell and Cell-free Circulating Tumor DNA in Lung Cancer
10.4068/cmj.2016.52.3.151
- Author:
Fariz NURWIDYA
1
;
Jamal ZAINI
;
Andika Chandra PUTRA
;
Sita ANDARINI
;
Achmad HUDOYO
;
Elisna SYAHRUDDIN
;
Faisal YUNUS
Author Information
1. Department of Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine, Persahabatan Hospital, Jakarta, Indonesia. fariz.nurwidya@gmail.com
- Publication Type:Review
- Keywords:
Neoplastic Cells, Circulating;
DNA, Neoplasm;
Lung Neoplasms;
Biology;
Methods
- MeSH:
Biology;
Blood Circulation;
Diagnosis;
DNA;
DNA, Neoplasm;
Lung Neoplasms;
Lung;
Methods;
Neoplasm Metastasis;
Neoplastic Cells, Circulating;
Prognosis
- From:Chonnam Medical Journal
2016;52(3):151-158
- CountryRepublic of Korea
- Language:English
-
Abstract:
Circulating tumor cells (CTCs) are tumor cells that are separated from the primary site or metastatic lesion and disseminate in blood circulation. CTCs are considered to be part of the long process of cancer metastasis. As a 'liquid biopsy', CTC molecular examination and investigation of single cancer cells create an important opportunity for providing an understanding of cancer biology and the process of metastasis. In the last decade, we have seen dramatic development in defining the role of CTCs in lung cancer in terms of diagnosis, genomic alteration determination, treatment response and, finally, prognosis prediction. The aims of this review are to understand the basic biology and to review methods of detection of CTCs that apply to the various types of solid tumor. Furthermore, we explored clinical applications, including treatment monitoring to anticipate therapy resistance as well as biomarker analysis, in the context of lung cancer. We also explored the potential use of cell-free circulating tumor DNA (ctDNA) in the genomic alteration analysis of lung cancer.
