Association between Vitamin D Status and Risk of Peripheral Arterial Disease: The Dong-gu Study
10.4068/cmj.2016.52.3.212
- Author:
Su Hyun OH
1
;
Sun Seog KWEON
;
Jin Su CHOI
;
Jung Ae RHEE
;
Young Hoon LEE
;
Hae Sung NAM
;
Seul Ki JEONG
;
Kyeong Soo PARK
;
So Yeon RYU
;
Seong Woo CHOI
;
Min Ho SHIN
Author Information
1. Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea. mhshinx@paran.com
- Publication Type:Original Article
- Keywords:
25-Hydroxyvitamin D;
Peripheral Arterial Disease;
Atherosclerosis
- MeSH:
Ankle;
Atherosclerosis;
Blood Pressure;
Cardiovascular Diseases;
Cross-Sectional Studies;
Logistic Models;
Myocardial Infarction;
Parathyroid Hormone;
Peripheral Arterial Disease;
Prevalence;
Risk Factors;
Stroke;
Vitamin D;
Vitamins
- From:Chonnam Medical Journal
2016;52(3):212-216
- CountryRepublic of Korea
- Language:English
-
Abstract:
Low levels of vitamin D have been associated with increased cardiovascular disease risk. However, few studies have evaluated the association between vitamin D status and peripheral arterial disease (PAD). We therefore aimed to investigate whether low 25-hydroxyvitamin D (25(OH)D) levels were associated with increased risk of PAD in the Korean population. This cross-sectional study was conducted among 8,960 subjects aged 50 years or older without known myocardial infarction or stroke. PAD was defined by an ankle brachial blood pressure index <0.9. Multivariate logistic regression was used to evaluate the association between serum 25(OH)D levels and risk of PAD. Of the 8,960 subjects, 3.0% had PAD and the age and sex adjusted prevalence of PAD decreased with the increasing 25(OH)D quartile. After adjusting for potential confounders and parathyroid hormones, serum 25(OH)D levels were associated with a significantly decreased risk of PAD (OR for one SD increase, 0.98; 95% CI, 0.95-1.0, P for trend=0.040). Compared with the first 25(OH)D quartile, the odds of PAD were 0.86 (95% CI, 0.62-1.21), 0.67 (95% CI, 0.46-0.97), and 0.71 (95% CI, 0.49-1.04) for the second, third, and fourth quartiles, respectively. In this cross-sectional study, we found that low serum 25(OH)D levels were associated with an increased risk of PAD, independent of traditional cardiovascular risk factors and parathyroid hormone. Our findings suggest that low vitamin D levels may contribute to PAD in the Korean population.
