Association of APOE Genotype with Bone Mineral Density in Men and Women: The Dong-gu and Namwon Studies
- Author:
Sun A KIM
1
;
Sun Seog KWEON
;
Jin Su CHOI
;
Jung Ae RHEE
;
Young Hoon LEE
;
Hae Sung NAM
;
Seul Ki JEONG
;
Kyeong Soo PARK
;
So Yeon RYU
;
Seong Woo CHOI
;
Hee Nam KIM
;
Hye Rim SONG
;
Su Hyun OH
;
Jane A CAULEY
;
Min Ho SHIN
Author Information
- Publication Type:Original Article
- Keywords: Apolipoprotein E; Polymorphism, genetic; Bone density
- MeSH: Absorptiometry, Photon; Apolipoproteins E; Asian Continental Ancestry Group; Bone Density; Cohort Studies; Dataset; Female; Femur Neck; Genotype; Humans; Jeollabuk-do; Male; Polymorphism, Genetic; Spine
- From:Chonnam Medical Journal 2016;52(1):59-63
- CountryRepublic of Korea
- Language:English
- Abstract: Many studies have investigated relationships between APOE genotype and bone mineral density (BMD). However, the results of these studies have been inconsistent. Few studies have been carried out in Asian populations. We studied the relationship of the APOE gene polymorphism and BMD in two large population-based studies. The datasets included the Dong-gu Study (3575 men and 5335 women) and the Namwon Study (2310 men, 3512 women). Lumbar spine and femoral neck BMD were measured by dual-energy X-ray absorptiometry. APOE genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism. The APOE genotypes were classified into APOE E2 (E2/E2 and E2/E3), APOE E3 (E3/E3), and APOE E4 (E3/E4 and E4/E4). The genotype distribution of the study population was in Hardy-Weinberg equilibrium. There were no significant differences among APOE genotype groups in lumbar and femoral neck BMD in either cohort. Our data do not support the hypothesis that the APOE genotype is associated with BMD.
