The infusion rate of mivacurium or atracurium for cesarean section compared with gynecological procedures.
10.3349/ymj.1999.40.4.371
- Author:
Jong Hoon KIM
1
;
Keong Tae MIN
;
Eun Kyoung AHN
;
Kun Ho KIM
;
Yang Sik SHIN
Author Information
1. Department of Anesthesiology, Yonsei University College of Medicine, Seoul, Korea. jhkim007@yumc.yonsei.ac.kr
- Publication Type:Original Article ; Comparative Study
- Keywords:
Neuromuscular block;
mivacurium;
atracurium;
cesarean section;
plasma cholinesterase
- MeSH:
Adult;
Atracurium/therapeutic use;
Atracurium/administration & dosage*;
Cesarean Section*;
Comparative Study;
Female;
Human;
Injections, Intramuscular;
Isoquinolines/therapeutic use;
Isoquinolines/administration & dosage*;
Neuromuscular Nondepolarizing Agents/therapeutic use;
Neuromuscular Nondepolarizing Agents/administration & dosage*;
Pregnancy
- From:Yonsei Medical Journal
1999;40(4):371-376
- CountryRepublic of Korea
- Language:English
-
Abstract:
Mivacurium is mainly metabolized by plasma cholinesterase, whereas atracurium is removed by Hofman elimination. The purpose of this study was to compare the infusion rate of atracurium and mivacurium in maintaining surgical relaxation, and to compare their recovery indices between parturients and non-pregnant women. Muscle relaxation was maintained by the continuous infusion of relaxants to retain the first response of train-of-four (TOF) at 5% of control. When mivacurium was used, Bolus-T5 (duration from the end of mivacurium bolus injection to 5% single twitch recovery) was measured. After discontinuing the infusion, the recovery index was measured. The infusion rate of mivacurium, not atracurium, was significantly lower in parturients and Bolus-T5 of parturients was significantly longer than that of non-pregnant women. There was no significant difference in the recovery indices of both relaxants. The authors concluded that the infusion rate of mivacurium in maintaining muscle relaxation in parturients should be reduced compared to the rate in non-pregnant women and measuring Bolus-T5 may be helpful in determining the infusion rate to maintain muscle relaxation.
