Apolipoprotein E polymorphism in non-diabetic patients with acute coronary syndrome.
10.3349/ymj.1999.40.4.377
- Author:
In Jai KIM
1
;
Bum Kee HONG
;
Byoung Kwon LEE
;
Hyuck Moon KWON
;
Dongsoo KIM
;
Eui Young CHOI
;
Ki Hyun BYUN
;
Jeong Ho KIM
;
Kyung Soon SONG
;
Hyun Seung KIM
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. bkhong@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Apolipoprotein E;
coronary artery disease;
acute coronary syndrome
- MeSH:
Apolipoproteins E/genetics*;
Coronary Disease/genetics*;
Genotype;
Human;
Polymorphism (Genetics)/genetics*;
Syndrome
- From:Yonsei Medical Journal
1999;40(4):377-382
- CountryRepublic of Korea
- Language:English
-
Abstract:
Since a decade ago, apolipoprotein (apo) E polymorphism has been focussed as a risk factor for cardiovascular disease. ApoE plays a central role as a receptor ligand for the uptake of lipoproteins from the circulation. There was an agreement on apoE polymorphism being one of the major risk factors for coronary artery disease (CAD) by its effects on lipid profiles. However, the effects of apoE have not been noted in all populations and conflicting results in the risk of CAD have been noted. Recently, in situ expression of apoE on the atherosclerotic plaque has been studied. We, therefore, investigated the effects of apoE genotype on patients with acute coronary syndrome, including unstable angina and acute myocardial infarction, in non-diabetic patients. While we could not find significant risk effects of apoE on coronary artery disease and lipid profiles on simple comparison with the normal control group, we could find significantly decreased frequencies of apo epsilon 3 allele in patients with acute coronary syndrome compared with stable angina patients (77.8% vs 88.8%). We suggest that the apoE genotype could be associated with acute coronary events in CAD and further study with in situ biochemical methods will be needed on the effects of apoE polymorphism on plaque stability.
