Effect of Atorvastatin-Eluting Stents in a Rabbit Iliac Artery Restenosis Model
10.4068/cmj.2013.49.3.118
- Author:
Kyung Seob LIM
1
;
Myung Ho JEONG
;
In Ho BAE
;
Jun Kyu PARK
;
Dae Sung PARK
;
Jong Min KIM
;
Jung Ha KIM
;
Dong Lyun CHO
;
Doo Sun SIM
;
Keun Ho PARK
;
Young Joon HONG
;
Youngkeun AHN
Author Information
1. Korea Cardiovascular Stent Institute of Chonnam National University, Gwangju, Korea. myungho@chollian.net
- Publication Type:Original Article
- Keywords:
Drug-eluting Stents;
Coronary Restenosis;
Hydroxymethylglutaryl-CoA Reductase Inhibitors;
Inflammation
- MeSH:
Blood Platelets;
Constriction, Pathologic;
Coronary Restenosis;
Drug-Eluting Stents;
Fibrin;
Hydroxymethylglutaryl-CoA Reductase Inhibitors;
Hyperplasia;
Iliac Artery;
Inflammation;
Neointima;
Rabbits;
Stents
- From:Chonnam Medical Journal
2013;49(3):118-124
- CountryRepublic of Korea
- Language:English
-
Abstract:
Statins have pleiotropic effects, which include the inhibition of neointima hyperplasia, the inhibition of vascular inflammation, and platelet inhibition. The aim of this study was to examine the effect of an atorvastatin-eluting stent (AES) in a rabbit iliac artery overstretch restenosis model. Ten rabbits were used in this study (10 rabbits, 10 iliac arteries for each stent). An AES and paclitaxel-eluting stent (PES) were implanted in the left and right iliac arteries in a rabbit (2 stents in each rabbit). The stents were deployed with oversizing (stent/artery ratio 1.3:1), and histopathologic analysis was assessed at 28 days after stenting. There were no significant differences in the injury score, lumen area, or inflammation score. There were significant differences in the neointimal area (0.7+/-0.18 mm2 in the AES group vs. 0.4+/-0.25 mm2 in the PES group, p<0.01), in the percentage stenosis area (14.8+/-5.06% in the AES group vs. 10.5+/-6.80% in the PES group, p<0.05), and in the fibrin score (0.4+/-0.51 in the AES group vs. 2.7+/-0.48 in the PES group, p<0.001). Although the AES did not suppress neointimal hyperplasia compared with the PES, it showed a superior arterial healing effect in a rabbit iliac artery overstretch restenosis model.
