The prognosis factors among breast cancer patients with extensive axillary lymph node metastasis
- Author:
Jae Myung KIM
1
;
Ju Yeon KIM
;
Eun Jung JUNG
;
Seung Jin KWAG
;
Ji Ho PARK
;
Taejin PARK
;
Sang Ho JEONG
;
Chi Young JEONG
;
Young Tae JU
;
Young Joon LEE
;
Soon Chan HONG
Author Information
- Publication Type:Original Article
- Keywords: Breast neoplasms; Prognosis; Lymphatic metastasis
- MeSH: Breast Neoplasms; Breast; Disease-Free Survival; Humans; Lymph Nodes; Lymphatic Metastasis; Neoplasm Metastasis; Prognosis; Retrospective Studies; Survival Rate
- From: Korean Journal of Clinical Oncology 2018;14(1):43-47
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: This study was designed to retrospectively identify prognostic factors of survival among breast cancer patients with 10 or more metastatic lymph nodes (LNs).METHODS: The study included 58 patients with 10 or more metastatic LNs who received standard treatment from January 2005 to December 2015. To identify the prognostic factors, we analyzed the difference of disease-free survival (DFS) according to clinicopathologic factors.RESULTS: The 5-year DFS and overall survival rates in all patients were 55% and 69%, respectively. Tumor size, number of metastatic LNs and ratio of metastatic to total LNs were associated with poorer prognosis. DFS was significantly poorer in patients with >15 than ≤15 metastatic LNs (hazard ratio [HR], 4.60; 95% confidence interval [CI], 1.38–15.32) and with LN ratio >0.64 than ≤0.64 (HR, 26.13; 95% CI, 3.16–215.80) A scoring system based on these factors was significantly prognostic of survival outcomes.CONCLUSION: This study identified factors of survival in breast cancer patients with extensive LN metastasis. Patients with unfavorable factors may require modified management to improve their clinical outcomes.
