Treatment of advanced stage cholangiocarcinoma: Systemic therapy may be the starting step for radical surgery
- Author:
HyungJoo BAIK
1
;
Sang Hyuk SEO
;
Kwang Hee KIM
;
Moon Young CHOI
;
Yo Han PARK
;
Chang Soo CHOI
Author Information
- Publication Type:Case Report
- Keywords: Cholangiocarcinoma; Gemcitabine; Cisplatin; Cholangiocarcinoma; Chemotherapy
- MeSH: Carcinoma, Hepatocellular; Cholangiocarcinoma; Cisplatin; Drug Therapy; Humans
- From: Korean Journal of Clinical Oncology 2018;14(1):62-65
- CountryRepublic of Korea
- Language:English
- Abstract: Cholangiocarcinoma is the most common biliary malignancy and the second most common hepatic malignancy following hepatocellular carcinoma. It can be classified anatomically as intrahepatic cholangiocarcinoma (iCCA), perihilar CCA, or distal CCA. The treatment of choice for iCCA is surgical resection, but only those with potentially resectable tumors can undergo surgery. The standard regimen for advanced stage iCCA is gemcitabine and cisplatin. We encountered two unusual cases of iCCA patients who were initially diagnosed as unresectable cases and underwent systemic chemotherapy, which showed great response and therefore enabled radical operation. The patients show that even though iCCA is a challenging disease, patients with good response to chemotherapy may have a chance to undergo radical surgery.
