Serine/arginine-rich splicing factors 2 (SRSF2) and SRSF4 expression patterns in Korean with colon cancer
- Author:
Jin Whi KIM
1
;
Do Sim PARK
;
Won Cheol PARK
;
Sora AHN
;
Dong Back KANG
;
Keun Young KIM
;
Yong KIM
Author Information
- Publication Type:Original Article
- Keywords: Colon cancer; Splicing factor; Serine/arginine-rich splicing factors 2; Serine/arginine-rich splicing factors 4
- MeSH: Carcinoembryonic Antigen; Carcinogenesis; Colon; Colonic Neoplasms; Colorectal Neoplasms; Humans; Ribonucleoproteins
- From: Korean Journal of Clinical Oncology 2016;12(2):115-118
- CountryRepublic of Korea
- Language:Korean
- Abstract: PURPOSE: Splicing factors play important roles in tumorigenesis. Serine/arginine-rich splicing factors 2 (SRSF2) and SRSF4 proteins, the members of SR family proteins, are dysregulated in various cancers. However, their protein expression levels and diagnostic values are unclear in colorectal cancer.METHODS: We quantified the protein levels of SRSF2, SRSF4, and previously known colon cancer markers (heterogeneous nuclear ribonucleoprotein A1 [HNRNPA1] and carcinoembryonic antigen [CEA]) in tumor compared with adjacent normal-looking areas (non-tumor) of the colon in Korean patients with colon cancer using immunoblot analysis.RESULTS: The protein levels of HNRNPA1 and CEA were remarkably increased in tumor compared to non-tumor tissue and up-regulated in all of the tumor samples. However, the protein levels of SRSF2 and SRSF4 in tumor tissue were reduced in contrast with those of non-tumor tissue.CONCLUSION: None of the SRSF proteins were significantly different between the low (≤II) and high (>II) stages.
