Pulmonary Hypertension in Preterm Infants With Bronchopulmonary Dysplasia.
10.4070/kcj.2010.40.3.131
- Author:
Hyo Soon AN
1
;
Eun Jung BAE
;
Gi Beom KIM
;
Bo Sang KWON
;
Jae Suk BEAK
;
Ee Kyung KIM
;
Han Suk KIM
;
Jung Hwan CHOI
;
Chung Il NOH
;
Yong Soo YUN
Author Information
1. Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea. eunjbaek@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Hypertension, pulmonary;
Infant, premature;
Bronchopulmonary dysplasia
- MeSH:
Birth Weight;
Bronchopulmonary Dysplasia;
Ductus Arteriosus, Patent;
Humans;
Hydrogen-Ion Concentration;
Hypertension, Pulmonary;
Infant;
Infant, Newborn;
Infant, Premature;
Mass Screening;
Oxygen;
Parturition;
Risk Factors;
Ventilators, Mechanical
- From:Korean Circulation Journal
2010;40(3):131-136
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: With the increasing survival of preterm infants, pulmonary hypertension (PH) related to bronchopulmonary dysplasia (BPD) has become an important complication. The aim of this study was to investigate the characteristics and outcome of PH in preterm infants with BPD and to identify the risk factors for PH. SUBJECTS AND METHODS: We reviewed the records of 116 preterm infants with BPD cared for at a single tertiary center between 2004 and 2008. RESULTS: Twenty-nine (25%) infants had PH >2 months after birth. PH occurred initially at a median age of 65 days (range, 7-232 days). Severe BPD, a birth weight <800 g, long-term ventilator care and oxygen supplementation, a high ventilator setting, infection, and a patent ductus arteriosus (PDA) were related to PH based on univariate analysis (p<0.05). The infants who had longer oxygen supplementation were significantly more likely to have PH (odds ratio, 18.5; 95% confidence interval, 4.1-84.6; p<0.001). PH was improved in 76% of infants after a median of 85 days (range, 20-765 days). Four infants (14%) died. The death of 3 infants was attributed to PH. CONCLUSION: BPD was frequently complicated by PH. Although PH resolved in the majority of infants, PH in preterm infants with BPD can be fatal. Regular screening for PH and adequate management are required.
