Treatment of Leukocytospermia in Male Infertility: A Systematic Review.
10.5534/wjmh.2016.34.3.165
- Author:
Jae Hung JUNG
1
;
Myung Ha KIM
;
Jiye KIM
;
Soon Koo BAIK
;
Sang Baek KOH
;
Hyun Jun PARK
;
Ju Tae SEO
Author Information
1. Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea.
- Publication Type:Review
- Keywords:
Infertility, male;
Leukocyte;
Semen analysis;
Therapeutics
- MeSH:
Anti-Bacterial Agents;
Antioxidants;
Free Radicals;
Humans;
In Vitro Techniques;
Infertility;
Infertility, Male*;
Inflammation;
Leukocytes;
Male;
Male*;
Mitochondria;
Oxygen;
Pregnancy Rate;
Semen Analysis;
Spermatozoa
- From:The World Journal of Men's Health
2016;34(3):165-172
- CountryRepublic of Korea
- Language:English
-
Abstract:
Male factors account for 20% to 50% of infertility cases, and infection in the genitourinary tract may play a contributing role in up to 15% of male infertility. Leukocytospermia is a well-known indicator of infection or inflammation in the male sex glands and the urogenital tract. Although great deal of effort has been expended to elucidate definite management strategies in infertile men with leukocytospermia, the gold standard of treatment remains unclear. Until recently, broad spectrum antibiotics and antioxidants have been used in the treatment of leukocytospermia for male infertility to eliminate infection and reduce reactive oxygen free radicals produced inside cellular mitochondria as a result of inflammation. The present review reveals that antibiotics might improve sperm parameters, the rate of resolution of leukocytospermia, the bacteriologic cure rate, and even the pregnancy rate, although some reports conflict. Antioxidants might also have clinical benefits for sperm function as shown by in vitro studies. However, the data are insufficient to conclude whether antibiotics and antioxidants for the treatment of infertile men with leukocytospermia are effective or not. Better designed investigations into leukocytospermia are needed.
