Anti-Inflammatory and Antimicrobial Effects of a Novel Herbal Formulation (WSY-1075) in a Chronic Bacterial Prostatitis Rat Model.
10.5534/wjmh.2016.34.3.179
- Author:
Jung Woo PARK
1
;
Hyun Cheol JEONG
;
Hyong Woo MOON
;
Shin Jay CHO
;
Jong Hyup YANG
;
Woo Hyun KIM
;
Woong Jin BAE
;
Jin Bong CHOI
;
Hyuk Jin CHO
;
U Syn HA
;
Sung Hoo HONG
;
Ji Youl LEE
;
Sae Woong KIM
Author Information
1. Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea. ksw1227@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Herbals;
Prostatitis;
Rats
- MeSH:
Animals;
Antioxidants;
Ciprofloxacin;
Cytokines;
Interleukin-6;
Interleukin-8;
Interleukins;
Models, Animal*;
Necrosis;
Prostate;
Prostatitis*;
Rats*;
Rats, Wistar;
Stem Cells;
Urethra
- From:The World Journal of Men's Health
2016;34(3):179-185
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The aim of this study was to investigate the anti-inflammatory and anti-oxidative effects of a multi-herbal formula known as WSY-1075 in the treatment of chronic bacterial prostatitis in a rat model. MATERIALS AND METHODS: Experimental chronic bacterial prostatitis was induced in 32 Wistar rats by instillation of a bacterial suspension (Escherichia coli, 10⁸ colony-forming units [CFU]/mL) into the prostatic urethra. After the induction of prostatitis, the rats were randomly divided into one of 4 treatment groups: control (n=8), ciprofloxacin (n=8), WSY-1075 (400 mg/kg) (n=8), and WSY-1075 (400 mg/kg)+ciprofloxacin (n=8). After 4 weeks of treatment, microbiological data from prostate tissue cultures, level of prostatic pro-inflammatory cytokines (tumor necrosis factor-α [TNF-α], interleukin [IL]-6, and IL-8), anti-oxidant effects (superoxide dismutase [SOD]), and histological findings were noted. RESULTS: The WSY-1075, ciprofloxacin, and WSY-1075+ciprofloxacin groups showed fewer CFUs in prostate tissue cultures than the control group. The WSY-1075, ciprofloxacin and WSY-1075+ciprofloxacin groups showed statistically significantly lower levels of the pro-inflammatory cytokines TNF-α, IL-6, and IL-8 than the control group. SOD levels in the WSY-1075, ciprofloxacin and WSY-1075+ciprofloxacin groups were significantly higher than in the control group. CONCLUSIONS: This study found that WSY-1075 had anti-microbial effects, anti-inflammatory effects, and anti-oxidative effects in a chronic bacterial prostatitis rat model. We expect the WSY-1075 may be useful for the clinical treatment of chronic bacterial prostatitis.
