Anti-thyroid peroxidase antibody and thyroid cysts among the general Japanese population: a cross-sectional study.
10.1186/s12199-020-00844-x
- Author:
Yuji SHIMIZU
1
;
Yuko NABESHIMA-KIMURA
2
;
Shin-Ya KAWASHIRI
3
;
Yuko NOGUCHI
3
;
Yasuhiro NAGATA
4
;
Takahiro MAEDA
3
;
Naomi HAYASHIDA
5
Author Information
1. Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-12-4, Nagasaki, 852-8523, Japan. shimizu@osaka-ganjun.jp.
2. Department of Radiation Health Management, Fukushima Medical University, Fukushima, Japan.
3. Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-12-4, Nagasaki, 852-8523, Japan.
4. Center for Comprehensive Community Care Education, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
5. Division of Promotion of Collaborative Research on Radiation and Environment Health Effects, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
- Publication Type:Journal Article
- Keywords:
Anti-thyroid peroxidase antibody;
Cross-sectional study;
Normal thyroid function;
Thyroid cysts;
Thyroid hormone
- From:Environmental Health and Preventive Medicine
2020;25(1):7-7
- CountryJapan
- Language:English
-
Abstract:
BACKGROUND:Anti-thyroid peroxidase antibody (TPO-Ab) has been shown to cause autoimmune thyroiditis by inducing a deleterious influence on thyroid hormone synthesis. Further, thyroglobulin, which has an important role in thyroid hormone synthesis, is reported to be high in the fluid from thyroid cysts. Therefore, TPO-Ab could be associated with the presence of thyroid cyst, partly by affecting the activity of thyroid hormone synthesis.
METHODS:To investigate the association between TPO-Ab and thyroid cysts, we conducted a cross-sectional study of 1432 Japanese with normal thyroid function [i.e., normal range of free triiodothyronine (free T3) and free thyroxine (free T4)] between the ages of 40 and 74 years, who participated in an annual health check-up.
RESULTS:In men, the statistical power did not reach a statistical significance value. Additionally, subjects with TPO-Ab showed lower odds ratios (ORs) of thyroid cysts than those without TPO-Ab. In women, subjects with TPO-Ab showed significantly lower ORs of thyroid cysts than those without TPO-Ab. The fully adjusted ORs were 0.68 (0.40, 1.18) for men and 0.40 (0.27, 0.60) for women. When evaluating the association between logarithmic values of TPO-Ab titer and thyroid cysts in both men and women, a notable inverse correlation was observed. The fully adjusted ORs were 0.68 (0.50, 0.92) for men and 0.68 (0.57, 0.81) for women.
CONCLUSION:TPO-Ab titer revealed to be inversely associated with thyroid cysts among Japanese with normal thyroid function. The presence of a thyroid cyst could indicate a lower risk of having TPO-Ab among the general population with normal thyroid function.
