Effect of neutrophil CD64 for diagnosing sepsis in emergency department
0.5847/wjem.j.1920-8642.2020.02.003
- Author:
Wen-peng Yin
1
;
Jia-bao Li
1
;
Xiao-fang Zheng
1
;
Le An
1
;
Huan Shao
1
;
Chun-sheng Li
1
Author Information
1. Department of Emergency Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
- Publication Type:Journal Article
- Keywords:
Neutrophil CD64;
Sepsis;
Sequential Organ Failure Assessment score;
Procalcitonin;
Prognosis;
Biomarker
- From:
World Journal of Emergency Medicine
2020;11(2):79-86
- CountryChina
- Language:English
-
Abstract:
BACKGROUND:The aim of this study is to investigate the diagnostic and prognostic value of neutrophil CD64 (nCD64) as a novel biomarker in sepsis patients.
METHODS: One hundred fifty-one adult patients diagnosed with sepsis and 20 age-matched healthy controls were enrolled in the study. Patients with sepsis were further subdivided into a sepsis group and a septic shock group. nCD64 expression, serum procalcitonin (PCT) level, C-reactive protein (CRP) level, and white blood cell (WBC) count were obtained for each patient, and Sequential Organ Failure Assessment (SOFA) scores were calculated.
RESULTS: nCD64 expression was higher in the sepsis group with confirmed infection than in the control group. The receiver operating characteristic (ROC) curve of nCD64 was higher than those of SOFA score, PCT, CRP and WBC for diagnosing infection. The area under the curve (AUC) of nCD64 combined with SOFA score was the highest for all parameters. The AUC of nCD64 for predicting 28-day mortality in sepsis was signifi cantly higher than those of PCT, CRP, and WBC, but slightly lower than that of SOFA score. The AUC of nCD64 or PCT combined with SOFA score was signifi cantly higher than that of any single parameter for predicting 28-day mortality.
CONCLUSION: nCD64 expression and SOFA score are valuable parameters for early diagnosis of infection and prognostic evaluation of sepsis patients.
