The Clinical Significance of Antiphospholipid Antibodies in Korean Children with Henoch-Schonlein Purpura.
- Author:
Eun Jung PARK
1
;
Ji Young BAEK
;
Jae Il SHIN
;
Jae Seung LEE
;
Hyon Suk KIM
Author Information
1. Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Henoch-Schonlein purpura;
Antiphospholipid antibodies;
Lupus anticoagulant
- MeSH:
Abdominal Pain;
Aged;
Antibodies, Antiphospholipid;
Arthralgia;
Blood Sedimentation;
C-Reactive Protein;
Child;
Glycoproteins;
Humans;
Immunoglobulin M;
Incidence;
Lupus Coagulation Inhibitor;
Medical Records;
Purpura, Schoenlein-Henoch;
Retrospective Studies
- From:Journal of the Korean Society of Pediatric Nephrology
2009;13(2):146-152
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We performed this study to evaluate the incidence and clinical significance of antiphospholipid antibodies (aPL Ab) in Korean children with Henoch-Schonlein purpura (HSP). METHODS: The medical records of 62 patients (31 boys and 31 girls) aged 6.0+/-3.1 (1-16) years with a clinical diagnosis of HSP based on the EULAR/PReS criteria were reviewed retrospectively. From the years 2007 to 2009, the sera from children with acute HSP were tested for aPL Ab such as LA, anti-cardiolipin antibody and anti-beta2 glycoprotein I antibody. RESULTS: LA was positive in 18 (29%) of the 62 patients with HSP and We divided the patients into the two groups LA positive group (N=18) and LA negative group (N=44). There were no significant differences between the two groups with regard to abdominal pain, arthralgia and renal involvement, but LA positive group had significantly higher C-reactive protein (4.3+/-7.2 mg/dL vs. 1.3+/-1.8 mg/dL, P=0.035), erythrocyte sedimentation rate (37.5+/-26.2 mm/hr vs. 25.1+/-22.6 mm/hr, P= 0.039), IgM (148.1+/-48.4 mg/dL vs. 114.9+/-41.5 mg/dL, P=0.024), C3 (143.1+/-21.9 mg/dL vs. 129.7+/-24.5 mg/dL, P=0.048) and C4 levels (30.9+/-6.3 mg/dL vs. 24.9+/-7.8 mg/dL, P=0.002) compared with LA negative group. CONCLUSION: We found that the incidence of positive aPL Ab tests was relatively higher in Korean children with HSP and the presence of aPL Ab was associated with acute inflammatory process of HSP. These results suggest that the aPL Ab are involved in the pathogenesis of HSP in children.
