Correlation between Serum Uric Acid and Carotid Intima-Media Thickness in Korean Women
10.21215/kjfp.2019.9.1.102
- Author:
Jiin JUNG
1
;
Sungmoon CHO
;
Deokhyun SHIN
;
Jongwoo KIM
;
Seon Yeong LEE
;
Kyunam KIM
;
Jeongki PAEK
Author Information
1. Department of Family Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. s2700@paik.ac.kr
- Publication Type:Original Article
- Keywords:
Uric Acid;
Carotid Intima-Media Thickness;
Menopause;
Women
- MeSH:
Blood Glucose;
Blood Pressure;
Body Mass Index;
Cardiovascular Diseases;
Carotid Intima-Media Thickness;
Creatinine;
Dyslipidemias;
Fasting;
Female;
Health Promotion;
Humans;
Hypertension;
Menopause;
Obesity;
Risk Factors;
Ultrasonography;
Uric Acid
- From:
Korean Journal of Family Practice
2019;9(1):102-107
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Serum uric acid (UA) has been found to be associated with hypertension, obesity, dyslipidemia, and metabolic syndrome; however, its role as an independent risk factor of cardiovascular disease (CVD) is still controversial. There have been very few studies reporting an association between UA levels and carotid intima-media thickness (CIMT), especially in women.METHODS: The study included 245 subjects whose CIMT was evaluated between February 2016 and December 2017 at a health promotion center. We divided the population into two groups on the basis of menopausal status: premenopausal women (n=78) and postmenopausal women (n=167). We measured blood pressure, serum lipid profile, fasting blood glucose (FBG), and creatinine and UA levels. CIMT was measured using high-resolution B-mode ultrasonography.RESULTS: UA levels and CIMT were higher in postmenopausal women (P=0.029, P < 0.001). In premenopausal women, age (r=0.438), body mass index (r=0.373), UA (r=0.205), and FBG (r=0.336) were associated with CIMT, whereas in postmenopausal women, age (r=0.326), body mass index (r=0.167), UA (r=0.166), systolic blood pressure (r=0.200), and HDL-cholesterol (r=−0.140) were associated with CIMT. The UA level was independently associated with CIMT in premenopausal women (β=0.208, P=0.031), whereas age was the only factor independently associated with CIMT in postmenopausal women (β=0.253, P=0.002). Women in the highest tertile of uric acid level exhibited a higher CIMT than did those in the lowest tertile after age adjustment (P for trend < 0.001).CONCLUSION: UA may be an independent risk factor for CIMT, suggesting that UA is a risk factor for the early detection of CVD, especially in premenopausal women.
