An Integrated Logistic Formula for Dose Prescription in Radiosurgery.
- Author:
Yong Gou PARK
1
;
Sang Sup CHUNG
;
Jin Woo CHANG
;
Jun CHO
;
Gi Hong KIM
Author Information
1. Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Gamma knife;
Radiosurgery;
Integrated loistic formula;
Radiation necrosis;
Dose-volume effect
- MeSH:
Necrosis;
Prescriptions*;
Radiation, Ionizing;
Radiosurgery*
- From:Journal of Korean Neurosurgical Society
1993;22(5):659-665
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Radiation necrosis is the main obstacle for radiosurgery delivering high dose ionizing radiation inhomogeneously into small field of lesion with spatial accuracy. The complication probability is closely related to dose-volume effect. To reduce the complication rate, the optimum dose should e prescribed for the isodose curve enclosing the target lesion according to the lesion volume and isodose fall-off. However, the shape, volume and isodose fall-off of the lesions are different from each other. To choose the optimum doses for radiosurgery in each case, it is necessary to have a reasonable model for predicting dose-volume effects. Flickinger developed an integrated logistic formula using normalized total dose(NTD) as a reasonable model to predict complications from gamma knife radiosurgery. The authors developed a computer program to calculate the risk probability using that formula. As previously emphasized, the risk probability derived from the formula is useful and indispensable as a guidance to dose prescription in gamma knife surgery.
