Various Classification of Gastric Adenocarcinoma
- Author:
Hee Seok MOON
1
;
Hyun Yong JEONG
Author Information
1. Division of Gastroenterology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea. jeonghy@cnu.ac.kr
- Publication Type:Review
- Keywords:
Gastric adenocarcinoma;
Classification;
Molecular biology
- MeSH:
Adenocarcinoma;
Classification;
Incidence;
Molecular Biology;
Mortality;
Phenotype;
Stomach Neoplasms
- From:
Journal of Digestive Cancer Report
2019;7(1):8-12
- CountryRepublic of Korea
- Language:English
-
Abstract:
Despite its declining incidence, gastric cancer is globally, still, the third most common cause of cancer-related mortality. Gastric cancer is a heterogeneous disease with diverse pathogenesis and molecular backgrounds. Therefore several systems have been proposed to aid in the classification of gastric adenocarcinoma based on the macroscopic, microscopic and anatomical features of the tumor. However, these classifications did not reflect the pathogenesis of the disease. Recently, genomic analysis has identified several subtypes of gastric adenocarcinoma and a detailed understanding of the molecular biology behind the neoplastic phenotype is possible to develop of more effective therapies. We will describe the existing various classification of gastric cancer and the recently introduced molecular biology and immunological classification.
