Extraordinary Response of Metastatic Pancreatic Cancer to Chemotherapy
- Author:
Dong Woo SHIN
1
;
Jinkook KIM
;
Jong Chan LEE
;
Jaihwan KIM
;
Jin Hyeok HWANG
Author Information
1. Division of Gastroenterology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. jhhwang@snubh.org
- Publication Type:Case Report
- Keywords:
Metastatic pancreatic cancer;
Gemcitabine;
Nanoparticle albumin-bound paclitaxel;
hENT1 immunohistochemical stain
- MeSH:
Adenocarcinoma;
Albumin-Bound Paclitaxel;
Back Pain;
Biopsy, Fine-Needle;
Drug Therapy;
Electrons;
Female;
Fluorodeoxyglucose F18;
Follow-Up Studies;
Humans;
Immunohistochemistry;
Lymph Nodes;
Middle Aged;
Nanoparticles;
Neoplasm Metastasis;
Nucleoside Transport Proteins;
Pancreatic Neoplasms;
Tail;
Tomography, X-Ray Computed;
Ultrasonography
- From:
Journal of Digestive Cancer Report
2019;7(1):22-25
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 58-year-old woman presented with right flank and back pain for one month. After undergoing an abdominal computed tomography (CT), she was referred to our hospital. The abdominal CT showed a hypodense pancreatic tail mass with multiple retroperitoneal lymph node metastases. Positron emission tomography-computed tomography (PET-CT) scan showed high 18F-FDG uptake in pancreatic tumor and enlarged lymph nodes. Endoscopic ultrasound fine needle aspiration (EUS-FNA) revealed adenocarcinoma, which stained strongly in hENT1 (human equilibrative nucleoside transporter 1) on immunohistochemistry. She received gemcitabine 1,000 mg/m² + nanoparticle albumin-bound paclitaxel 125 mg/m² as a palliative chemotherapy. Follow-up abdominal CT and PET-CT after 4 cycles of chemotherapy showed that both pancreatic mass and the metastatic retroperitoneal lymph nodes were nearly disappeared. We report a case of 58-year-old female with metastatic pancreatic cancer who had a dramatic response to palliative chemotherapy (gemcitabine plus nanoparticle albumin-bound paclitaxel).
