Effect of Sodium Cromoglycate on Acetic Acid-induced Ulcerative Colitis in Mice
- Author:
Zahra GHAFOURI
1
;
Saeid SEYYEDIAN
;
Jafar NIKBAKHT
;
Ebrahim KOUHSARI
;
Sara BAYAT
;
Hamidreza ZARGAR
;
Gholamreza HOUSHMAND
Author Information
- Publication Type:Original Article
- Keywords: Sodium cromoglycate; Acetic acid; Colitis, ulcerative
- MeSH: Acetic Acid; Animals; Colitis, Ulcerative; Colon; Cromolyn Sodium; Glucocorticoids; Inflammatory Bowel Diseases; Mice; Rats; Sodium; Sulfasalazine; Ulcer
- From:The Korean Journal of Gastroenterology 2020;75(1):39-45
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Ulcerative colitis (UC) is a type of inflammatory bowel disease that mainly involves the colon. Thus far, glucocorticoids and amino-salicylate have been the main treatment.METHODS: To assess drugs with fewer side effects, this study evaluated the effects of sodium cromoglycate (SCG) on acetic acid-induced UC in rats. The treatment groups included SCG receivers (50 and 100 mg/kg, intra-orally) and sulfasalazine (SSZ) receivers (100 mg/kg, intra-orally). The colonic mucosal injury was assessed by clinical, macroscopic, and histopathological examinations.RESULTS: In the treatment groups with 50 and 100 mg/kg of SCG, the clinical activity score decreased to 2.67±0.18 and 1.73±0.21 (p<0.05), respectively, compared to the UC control group (3.21±0.31), and were higher than that of the group given the standard treatment of 100 mg/kg SSZ (1.10±0.09). The treatment groups with 50 and 100 mg/kg of SCG showed a lower clinical gross lesion score than the UC control group (2.91±0.28 and 2.10±0.43, vs. 4.49±0.61, p<0.05) and were higher than the standard group (0.95±0.18). Treatment with SCG (100 mg/kg) decreased the macroscopic scores significantly compared to the UC control group (p<0.05) on the 8th day.CONCLUSIONS: SCG (100mg/kg) decreased significantly the clinical activity score, gross lesion, and percentage-affected area compared to the UC controls on the 8th day.
