Role of Gut Microbiota in Type 2 Diabetes Mellitus and Its Complications: Novel Insights and Potential Intervention Strategies
10.4166/kjg.2019.74.6.314
- Author:
Birhanu WOLDEAMLAK
1
;
Ketsela YIRDAW
;
Belete BIADGO
Author Information
1. Clinical Chemistry Laboratory, University of Gondar Hospital, Gondar, Ethiopia.
- Publication Type:Review
- Keywords:
Type 2 diabetes mellitus;
Gastrointestinal microbiome
- MeSH:
Archaea;
Bacteria;
Bacteriophages;
Bariatric Surgery;
Diabetes Mellitus, Type 2;
Dysbiosis;
Ecosystem;
Fecal Microbiota Transplantation;
Fungi;
Gastrointestinal Microbiome;
Genetic Predisposition to Disease;
Homeostasis;
Humans;
Inflammation;
Intestines;
Prebiotics;
Probiotics;
Public Health;
Virion
- From:The Korean Journal of Gastroenterology
2019;74(6):314-320
- CountryRepublic of Korea
- Language:English
-
Abstract:
Type 2 diabetes mellitus has become one of the fastest growing public health problems worldwide. The disease is believed to involve a complex process involving genetic susceptibility and environmental factors. The human intestine harbors hundreds of trillions of bacteria, as well as bacteriophage particles, viruses, fungi, and archaea, which constitute a complex and dynamic ecosystem referred to as the gut microbiota. Increasing evidence has indicated changes in the gut microbiota composition or function in type 2 diabetic patients. An analysis of ‘dysbiosis’ enables the detection of alterations in the specific bacteria, clusters of bacteria, or bacterial functions associated with the occurrence of type 2 diabetes. These bacteria are involved predominantly in the control of inflammation and energy homeostasis. This review attempts to show that the gut microbiota are important factors for the occurrence of type 2 diabetes and are important for the treatment of gut microbiota dysbiosis through bariatric surgery, fecal microbiota transplantation, prebiotics, and probiotics.
