Meta-analysis on risk stratification of malignant ventricular tachyarrhythmic events in arrhythmogenic right ventricular cardiomyopathy
10.12701/yujm.2017.34.2.208
- Author:
Young Eun ROH
1
;
Hyun Ji JANG
;
Min Jung CHO
Author Information
1. Medical Research Institute of Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. mjchomd@gmail.com
- Publication Type:Meta-Analysis
- Keywords:
Arrhythmogenic right ventricular cardiomyopathy;
Defibrillator;
Sudden death;
Ventricular tachyarrhythmia;
Meta-analysis
- MeSH:
Arrhythmias, Cardiac;
Arrhythmogenic Right Ventricular Dysplasia;
Cardiomyopathies;
Child;
Death, Sudden;
Death, Sudden, Cardiac;
Defibrillators;
Electrophysiology;
Humans;
Odds Ratio;
Risk Factors;
Tachycardia;
Tachycardia, Ventricular;
Ventricular Dysfunction, Right;
Young Adult
- From:Yeungnam University Journal of Medicine
2017;34(2):208-215
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a cardiomyopathy characterized by predominant right ventricular fibro-fatty replacement, right ventricular dysfunction and ventricular arrhythmias. It is a rare but important cause of sudden cardiac death in children and young adults. A meta-analysis on risk stratification of major ventricular tachyarrhythmic events indicating the need for implantable cardioverter defibrillator therapy in ARVC was performed.METHODS: The pubmed database was searched from its inception to May 2015. Of the 433 citations identified, 12 were included in this meta-analysis. Data regarding major ventricular tachyarrhythmic events were retrieved in 817 subjects from the studies. For the variables, a combined odds ratio (OR) was calculated using a fixed-effects meta-analysis.RESULTS: Extensive right ventricular dysfunction (OR, 2.44), ventricular late potential (OR, 1.66), inducible ventricular tachyarrhythmia during electrophysiology study (OR, 3.67), non-sustained ventricular tachycardia (OR, 3.78), and history of fatal event/sustained VT (OR, 5.66) identified as significant risk factors (p < 0.0001).CONCLUSION: This meta-analysis shows that extensive right ventricular dysfunction, ventricular late potential, inducible ventricular tachyarrhythmia during electrophysiological study, non-sustained ventricular tachycardia, and history of sustained ventricular tachycardia/fibrillation are consistently reported risk factors of major ventricular tachyarrhythmic events indicating implantable cardioverter defibrillator therapy in patients with ARVC.
