Predictive Value of Preoperative Volume-Based 18F-2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography/Computed Tomography Parameters in Patients with Resectable Lung Adenocarcinoma
10.1007/s13139-018-0555-4
- Author:
Sunju CHOI
1
;
Hye Ryeong KWON
;
Hee Young CHO
;
Kisoo PAHK
;
Sung Ho LEE
;
Jae Ho CHUNG
;
Hyun Woo KWON
;
Sungeun KIM
Author Information
1. Department of Nuclear Medicine, Korea University Anam Hospital, 73, Inchon-ro, Seongbuk-gu, Seoul 02841, Republic of Korea. hnwoo00@gmail.com
- Publication Type:Original Article
- Keywords:
Lung adenocarcinoma;
FDG PET/CT;
Recurrence;
Metabolic tumor volume;
Total lesion glycolysis
- MeSH:
Adenocarcinoma;
Cohort Studies;
Electrons;
Female;
Fluorodeoxyglucose F18;
Follow-Up Studies;
Glycolysis;
Humans;
Lung;
Male;
Methods;
Multivariate Analysis;
Positron-Emission Tomography and Computed Tomography;
Recurrence;
Retrospective Studies;
Tumor Burden
- From:Nuclear Medicine and Molecular Imaging
2018;52(6):453-461
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study aimed to investigate the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG), which are volume-based PET parameters, using 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) in patients with surgically resectable lung adenocarcinoma.METHODS: We retrospectively evaluated 149 patients with lung adenocarcinoma who underwent 18F-FDG PET/CT before surgical resection. Maximum standardized uptake value (SUVmax), MTV, and TLG of the primary tumor with threshold value of SUVmax 30, 40, and 50% were calculated, respectively. To compare the predictive performance of volume-based PET parameters, recurrence-free survival was assessed using the Kaplan-Meier method.RESULTS: The study included 70 males and 79 females with an average age of 65.8 years. The median follow-up time was 45.4 months. Recurrence was observed in 53 patients (35.6%). The mean ± SD SUVmax, MTV30%, and TLG(30%) of the entire cohort were 4.79 ± 2.94, 19.45 ± 24.85, and 56.43 ± 101.88, respectively. The cut-off values of MTV30% and TLG(30%) for recurrence were 11.07 ad 30.56, respectively. The 1-year recurrence-free survival (RFS) rate was 96.5% in low-MTV30% patients compared with 86.2% in high-MTV30% patients (p = 0.018) and 96.0% in low-TLG(30%) patients compared with 88.5% in high-TLG(30%) patients (p < 0.001). On univariate and multivariate analysis, TLG(30%) (HR, 2.828, p < 0.001; HR, 2.738, p < 0.001, respectively) was an independent prognostic factor for predicting recurrence-free survival (RFS).CONCLUSION: TLG(30%) value was observed to be a significant prognostic factor for RFS in patients with lung adenocarcinoma treated by surgical resection.
