Langerhans' Cell Histiocytosis Masquerading as Metastatic Papillary Thyroid Cancer on F-18 FDG PET/CT: Diagnostic Dilemma Solved by PET/CT-Guided Biopsy
10.1007/s13139-018-0536-7
- Author:
Dharmender MALIK
1
;
Rajender KUMAR
;
Bhagwant Rai MITTAL
;
Gaurav PARKASH
;
Amanjit BAL
;
Anish BHATTACHARYA
Author Information
1. Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India. drrajender2010@gmail.com
- Publication Type:Case Report
- Keywords:
Papillary thyroid cancer;
Langerhans' cell histiocytosis;
Anti-thyroglobulin level;
¹⁸F-FDG PET/CT;
PET/CT-guided biopsy
- MeSH:
Biopsy;
Diagnosis;
Follow-Up Studies;
Histiocytosis;
Iodine;
Neoplasm Metastasis;
Positron-Emission Tomography and Computed Tomography;
Thyroglobulin;
Thyroid Gland;
Thyroid Neoplasms;
Thyroxine
- From:Nuclear Medicine and Molecular Imaging
2018;52(5):394-397
- CountryRepublic of Korea
- Language:English
-
Abstract:
We present a case of papillary thyroid cancer (post-thyroidectomy status) on regular treatment with suppressive Levothyroxine therapy. On follow-up at 6 months after radioactive iodine ablation for remnant thyroid tissue, her thyroglobulin, and anti-thyroglobulin levels were 0.06 ng/ml and 670 IU/ml, respectively. Low-dose whole-body I-131 scan was negative. To look for the cause of isolated increased anti-thyroglobulin level, a whole-body ¹⁸F-FDG PET/CT was done which revealed multiple FDG-avid lytic skeletal lesions suggestive of metastases. For confirmation of diagnosis, ¹⁸F-FDG PET/CT-guided metabolic biopsy was done, which revealed Langerhans' cell histiocytosis on histopathological examination.
