Bone and Calcified Soft Tissue Metastases of Medullary Thyroid Carcinoma Better Characterized on ¹⁸F-Fluoride PET/CT than on ⁶⁸Ga-Dotatate PET/CT
10.1007/s13139-018-0527-8
- Author:
Paulo Schiavom DUARTE
1
;
Luciana Audi DE CASTRONEVES
;
Heitor Naoki SADO
;
Marcelo Tatit SAPIENZA
;
Ana Amélia Fialho DE OLIVEIRA HOFF
;
Carlos Alberto BUCHPIGUEL
Author Information
1. Division of Nuclear Medicine, São Paulo Cancer Institute (ICESP), Av. Dr. Arnaldo, 251, 4° SS, Cerqueira César, São Paulo, SP 01246-000, Brazil. psduarte@hotmail.com
- Publication Type:Case Report
- Keywords:
Medullary thyroid carcinoma;
Gallium-68;
⁶⁸Ga;
¹⁸F;
¹⁸F-NaF;
PET/CT
- MeSH:
Drug Therapy;
Electrons;
Humans;
Lymph Nodes;
Multiple Endocrine Neoplasia Type 2b;
Neoplasm Metastasis;
Positron-Emission Tomography and Computed Tomography;
Radiotherapy;
Thyroid Gland;
Thyroid Neoplasms;
Thyroidectomy;
Young Adult
- From:Nuclear Medicine and Molecular Imaging
2018;52(4):318-323
- CountryRepublic of Korea
- Language:English
-
Abstract:
Herein, we report a case of a 19-year-old man with multiple endocrine neoplasia type 2B (MEN2B) and medullary thyroid carcinoma (MTC) diagnosed when he was 12 years of age. The patient had previously undergone total thyroidectomy, cervical radiotherapy, and chemotherapy. He progressed with known bone, pulmonary, and lymph node metastases and was scanned with ¹⁸F-fluoride (¹⁸F-NaF) and ⁶⁸Ga-dotatate whole-body positron emission tomography/computed tomography (PET/CT) for metastatic disease monitoring.We found that the MTC bone metastases and soft tissue calcified metastases were better characterized on ¹⁸F-NaF PET/CT than on ⁶⁸Ga-dotatate PET/CT. This case illustrates that the ¹⁸F-NaF PET/CT could be helpful not only to the detection of bone metastases but also to the detection of calcified soft tissue metastases in patients with MTC.
