A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats as Revealed by Positron Emission Tomography Using ¹¹CPK11195
10.1007/s13139-017-0510-9
- Author:
Miho OTA
1
;
Jun OGURA
;
Shintaro OGAWA
;
Koichi KATO
;
Hiroshi MATSUDA
;
Hiroshi KUNUGI
Author Information
1. Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan. ota@ncnp.go.jp
- Publication Type:Original Article
- Keywords:
[¹¹C]PK11195;
Glial cells;
Lipopolysaccharides;
Positron emission tomography;
Somatosensory area
- MeSH:
Adult;
Animals;
Brain;
Depression;
Electrons;
Humans;
Immunity, Innate;
Injections, Intraperitoneal;
Lipopolysaccharides;
Male;
Neuroglia;
Positron-Emission Tomography;
Rats;
Rats, Inbred F344
- From:Korean Journal of Nuclear Medicine
2018;52(3):224-228
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo.METHODS: Ten adult male Fischer F344 rats underwent [¹¹C]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [¹¹C]PK11195 between before and after injection was determined.RESULTS: There was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas.CONCLUSIONS: Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [¹¹C]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [¹¹C]PK11195 PET would clarify the relationships between neuroinflammation and depression.
