Longitudinal Decline of Striatal Subregional ¹⁸FFP-CIT Uptake in Parkinson's Disease
10.1007/s13139-017-0481-x
- Author:
Changhwan SUNG
1
;
Jai Hyuen LEE
;
Jungsu S OH
;
Minyoung OH
;
Sang Ju LEE
;
Seung Jun OH
;
Sun Ju CHUNG
;
Chong Sik LEE
;
Jae Seung KIM
Author Information
1. Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympicro 43-gil, Songpa-gu, Seoul 05505, South Korea. jaeskim@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
[¹⁸F]FP-CIT pet;
Parkinson's disease;
Longitudinal decline;
Dopamine transporter imaging
- MeSH:
Aged;
Diagnosis;
Dopamine Plasma Membrane Transport Proteins;
Follow-Up Studies;
Humans;
Parkinson Disease;
Putamen;
Retrospective Studies
- From:Nuclear Medicine and Molecular Imaging
2017;51(4):304-313
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Dopamine transporter imaging is suggested to be a useful imaging biomarker for Parkinson's disease (PD) progression and monitoring drug effects.We investigated the longitudinal decline characteristics of striatal [¹⁸F]FP-CIT uptake in PD.METHODS: We retrospectively reviewed 35 PD patients and 9 non-PD patients. All patients underwent [¹⁸F]FP-CIT PET at the initial diagnosis and follow-up. PET images were spatially normalized and analyzed with eight striatal and one occipital VOI templates. We measured the specific to non-specific binding ratio (SNBR) of the striatal subregions and calculated the absolute annual reduction (AAR) and relative annual reduction (%RAR) of the SNBRs.RESULTS: Total striatal SNBRs in PD patients were significantly lower than those in non-PD patients, with the most significant difference in the posterior putamen. Both AAR (0.26 ± 0.14 vs. 0.09 ± 0.19, p < 0.05) and %RAR (6.9 ± 3.5 vs. 1.2 ± 2.7, p < 0.001) of total striatal SNBRs were significantly greater in PD than non-PD patients. There were no significant differences in the AAR and %RAR of total striatal SNBRs between elderly and young onset PD. The AARs of the posterior putamen were higher in early PD than in advanced PD. Conversely, the %RARs were not significantly different between early and more advanced PD. The disease duration was significantly negatively correlated with the AAR but not with the %RAR of the posterior putamen.CONCLUSIONS: The longitudinal decline of striatal [¹⁸F]FP-CIT uptake in PD was nonlinear and significantly faster than that in non-PD, with a different rate of decline among the striatal subregions.
