Prognostic Value of Tumor-to-Blood Standardized Uptake Ratio in Patients with Resectable Non-Small-Cell Lung Cancer
10.1007/s13139-016-0456-3
- Author:
Seunghyeon SHIN
1
;
Kyoungjune PAK
;
In Joo KIM
;
Bum Soo KIM
;
Seong Jang KIM
Author Information
1. Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea. forladou@naver.com, ilikechopin@daum.net, injkim@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Fluorodeoxyglucose F18;
Positron-emission tomography;
Prognosis;
Non-small-cell lung cancer;
Recurrence;
Survival
- MeSH:
Aorta, Thoracic;
Electrons;
Fluorodeoxyglucose F18;
Glycolysis;
Humans;
Lung Neoplasms;
Lung;
Methods;
Positron-Emission Tomography;
Prognosis;
Recurrence;
ROC Curve;
Tumor Burden
- From:Nuclear Medicine and Molecular Imaging
2017;51(3):233-239
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: Previously published studies showed that the standard tumor-to-blood standardized uptake value (SUV) ratio (SUR) was a more accurate prognostic method than tumor maximum standardized uptake value (SUV(max)). This study evaluated and compared prognostic value of positron emission tomography (PET) parameters and normalized value of PET parameters by blood pool SUV in non-small-cell lung cancer (NSCLC) patients who received curative surgery.METHODS: Seventy-seven patients who underwent curative resection for NSCLC between January 2010 to December 2013 were enrolled in this study. ¹⁸Fluorine-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) was performed before surgery. The mean standardized uptake value (SUV(mean)), SUV(max), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of each lesion was measured, on the workstation. SUR(mean), SUR(max), and TLGSUR were calculated by dividing each of them by descending aorta SUV(mean). Cox proportional hazards regression was used to analyze the effect of age, sex, pathological parameters, and PET parameters on recurrence and death.RESULTS: In Cox regression analysis, N stage predicted for both recurrence (p < 0.0001) and death (p < 0.0001). SUR(max) predicted recurrence (p = 0.0014), not death. Area under the receiver operating characteristic curve of SUR(max) was 0.759 with cutoff value 4.004. However, SUV(max), SUV(mean), MTV, TLG, SUR(mean), and TLGSUR predicted neither recurrence nor death.CONCLUSIONS: Among PET parameters, SUR(max) was the independent predictor of recurrence in NSCLC patients who received curative surgery. N stage was the independent prognostic factor for both recurrence and death. Both parameters could be used to stratify the risk of NSCLC patients.
