Combined approaches using adverse outcome pathways and big data to find potential diseasesassociated with humidifier disinfectant
- Author:
Jong Han LEEM
1
;
Kyu Hyuck CHUNG
Author Information
- Publication Type:Original Article
- Keywords: Humidifier disinfectant disease; Adverse outcome pathway; Reactive oxygen species; T- cell decrease; Pro-inflammatory cytokine
- MeSH: Asthma; Autoimmune Diseases; Bronchioles; Dermatitis; Fetal Death; Fibrosis; Humidifiers; Knowledge Bases; Macrophages; National Health Programs; Pneumonia; Reactive Oxygen Species; Rhinitis, Allergic; T-Lymphocytes
- From:Environmental Health and Toxicology 2017;32(1):2017003-
- CountryRepublic of Korea
- Language:English
- Abstract: According to previous survey, about two million of people were expected to suffer from toxic effects due to humidifier disinfectant (HD), regardless of healing or not. Extremely small group are recognized as HDs’ victims. Up to now, previous research tried to focus on interstitial fibrosis on terminal bronchiole because it is specific finding, compared with other diseases. To figure out overall effects from HDs, we recommend adverse outcome pathways (AOPs) as new approach. Reactive oxygen species (ROS) generation, decreased T-cell and pro-inflammatory cytokine release from macrophage could be key events between the exposure to HDs and diseases. ROS generation, decreased cell and pro-inflammatory cytokine release from macrophage could be cause of interstitial fibrosis, pneumonia and many other diseases such as asthma, allergic rhinitis, allergic dermatitis, fetal death, premature baby, autoimmune disease, hepatic toxicity, renal toxicity, cancer, and so on. We predict potential disease candidate by AOPs. We can validate the real risk of the adverse outcome by epidemiologic and toxicologic study using big data such as National Health Insurance data and AOPs knowledge base. Application of these kinds of new methods can find the potential disease list from the exposure to HD.
