Elucidation of the pathophysiology of intradialytic muscle cramps: pharmacokinetics applied to translational research
10.12793/tcp.2019.27.4.119
- Author:
Arthur J ATKINSON
1
Author Information
1. Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. art_atkinson@msn.com
- Publication Type:Clinical Trial
- Keywords:
Capillary physiology;
Hemodialysis;
Intradialytic cramps;
Pharmacokinetics;
Renin-angiotensin system;
Sympathetic nervous system
- MeSH:
Humans;
Muscle Cramp;
Muscle, Skeletal;
Pharmacokinetics;
Renal Dialysis;
Renin-Angiotensin System;
Sympathetic Nervous System;
Systems Analysis;
Translational Medical Research
- From:Translational and Clinical Pharmacology
2019;27(4):119-122
- CountryRepublic of Korea
- Language:English
-
Abstract:
In the conventional concept of translational research, investigations flow from the laboratory bench to the bedside. However, clinical research can also serve as the starting point for subsequent laboratory investigations that then lead back to the bedside. This article chronicles the evolution of a series of studies in which a detailed analysis of pharmacokinetics in hemodialysis patients revealed new physiological insight that, through a systems approach incorporating kinetic, physicochemical, physiologic, and clinical trial results, led to an elucidation of the pathophysiology of intradialytic skeletal muscle cramps. Based on this understanding, a therapeutic path forward is proposed.
