Changing Susceptibility of Staphylococcus aureus in Children with Skin and Soft Tissue Infections: a Single Center Experience from 2010 to 2018
- Author:
Yong Sun CHO
1
;
Shin Hye LEE
;
Taek Jin LEE
Author Information
- Publication Type:Original Article
- Keywords: Staphylococcus aureus; Staphylococcal skin infections; Methicillin-resistant
- MeSH: Child; Humans; Methicillin Resistance; Observational Study; Oxacillin; Retrospective Studies; Skin; Soft Tissue Infections; Staphylococcal Skin Infections; Staphylococcus aureus; Staphylococcus; Tetracycline
- From:Pediatric Infection & Vaccine 2019;26(3):140-147
- CountryRepublic of Korea
- Language:Korean
- Abstract: PURPOSE: Staphylococcus aureus is a major cause of skin and soft tissue infections (SSTIs). This study aimed to determine the temporal trends in antibiotic susceptibility of S. aureus in SSTI patients aged <19 years.METHODS: This retrospective observational study was conducted in pediatric patients with SSTI caused by community-associated S. aureus. Microbiologic and demographic data were collected, and the trends of antibiotic susceptibility results were evaluated.RESULTS: From January 2010 to December 2018, a total of 807 S. aureus isolates were included. An overall increase in susceptibility of isolates to oxacillin was noted (P<0.001), with 75.0% of isolates being oxacillin-susceptible in 2018. S. aureus remained highly susceptible to trimethoprim/sulfamethoxazole and tetracycline, with 97.6% and 95.2% isolate susceptibility in 2018, respectively. Isolates from younger children aged 1 to 5 years had a significantly lower rate of susceptibility to oxacillin than older children aged 6 to 18 years (53.4% vs. 75.0%, P<0.001).CONCLUSIONS: The proportion of methicillin-resistant S. aureus isolates appears to decrease in pediatric patients with community-associated SSTI caused by S. aureus. Clinicians should be aware of regional susceptibility patterns when choosing empirical regimens.
