Perspectives in TSPO PET Imaging for Neurologic Diseases
10.1007/s13139-019-00620-y
- Author:
Yoo Sung SONG
1
Author Information
1. Seoul National University Bundang Hospital, Seongnam, South Korea. yosung99@hanmail.net
- Publication Type:Brief Communication
- Keywords:
Neuroinflammation;
Neurologic disease;
Positron emission tomography;
Translocator protein (18 kDa)
- MeSH:
Nervous System Diseases;
Positron-Emission Tomography
- From:Nuclear Medicine and Molecular Imaging
2019;53(6):382-385
- CountryRepublic of Korea
- Language:English
-
Abstract:
The translocator protein (18 kDa) (TSPO) is a mitochondrial transmembrane protein, which has brought attention as a neuroinflammatory biomarker. Positron emission tomography (PET) imaging studies have been done for several decades, since neuroinflammation has been implicated as an important pathophysiology of several common neurologic disorders. However, despite numerous previous studies with positive findings, its clinical significance is not yet clear. Various attempts to overcome the limitations are ongoing, in order to bring acceptance for use in clinics.
